Cisplatin ld50 in mice

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WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 3 of 7 Version: 1.1 7. HANDLING AND STORAGE ... Rat Oral LD50 3000 mg/kg Sodium chloride Eye Irritation Rabbit Moderate Mouse Oral LD 50 4000 mg/kg Mouse Oral LD 50 32.7 mg/kg ... WebThe widespread outer hair cell lesions that develop in mice treated with cisplatin plus furosemide could serve as extremely useful murine model for investigating techniques for regenerating outer hair cells, studying the mechanisms of cisplatin and furosemide …

LD 50 of cisplatin and NPs-cp. Download Table

WebDec 21, 2024 · Mice were divided into a control group, cisplatin-treated group, and cisplatin + myo-inositol-treated group, which were treated with cisplatin or myo-inositol accordingly. Mice received intraperitoneal injection of cisplatin at a dose of 25 mg/kg, and they were sacrificed by cervical dislocation three days later. WebOct 1, 2024 · In addition, significant immune cell infiltration was observed in the kidney after four doses of 9 mg/kg cisplatin, contrary to what has been previously reported. These results indicate that multiple strains of mice can be used with our repeated low-dose … can be nested

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

WebApr 13, 2024 · Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex malignant diseases with a high level of heterogeneity and, as a result, a wide range of therapeutic responses ... WebThe 50% lethal dose (LD50) of cisplatin in S3 cells was 4 x 10 (-5) M after 20 h incubation and 8.5 x 10 (-6) M after 40 h incubation. Outer medullary collecting duct (OMCD) cells were damaged 30% maximally after 20 h incubation with cisplatin, and LD50 in them became 2.5 x 10 (-5) M after 40 h incubation. WebDec 1, 1987 · Calculated pharmacokinetic parameters (peak concentrations, half-lives, areas under the curve) were compared with the corresponding values in patients at the maximal tolerated dose. Peak plasma concentrations were 2.4- to 20-fold higher in mice than in humans. Initial and terminal half-lives in mice were up to 6 times shorter than in … fishing fabric mod

Cisplatin-Induced Rodent Model of Kidney Injury

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WebHowever, the immune tolerance limits the effect of chemotherapeutic drugs. Therefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in the present study, and we found that cisplatin increased the expression level of YAP1 in the mouse liver with H22 cells. WebApr 25, 2014 · Cisplatin (dichlorodiamino platinum) is an inorganic platinum-based chemotherapeutic agent that is widely used in the treatment of a variety of solid malignant tumors such as head and neck, lung, testis, ovarian, and bladder cancers [9]. can benepali cause high blood pressureWebThe mice were sacrificed on the 35th day from the first injection. Estimation of Acute Toxicity of Polycisplatin. ICR mice (5 weeks old) weighing 20–23 g were subjected to a study to measure the lethal dose (LD 50) of Polycisplatin to compare with that of cisplatin. The mice were randomly divided into six groups with four mice each. can be negotiated

"WebSep 1, 2024 · The serum of nutlin-3a or cisplatin-treated mice was obtained 4 h after LPS injection. Tissues of nutlin-3a or cisplatin-treated mice were obtained 12 h after LPS injection. Survival of mice was monitored after an i.p. injection of LPS (60 mg/kg) or E. coli (1 × 10 8 CFU). " - Cisplatin ld50 in mice

Cisplatin ld50 in mice

Cisplatin promotes the expression level of PD-L1 in the

WebNude mice were divided into 3 groups (etoposide, cisplatin and MTX-group), 7 to 9 per group and received drug treatment which started when their tumor grew to 100 approximately 300 mm3 in volume. All drugs were intraperitoneally administrated to nude mice (each drug: 1/4 mouse LD50 dose X3, weekly). WebProtocol (AUP). The MSDS must be attached to the AUP. 5.2. General precautions: 5.2.1. Pregnant or breast -feeding women should not work with cisplatin. 5.2.2. The following personal protective equipment mu st be worn at all times when handling cisplatin (in addition to the personal protective requirements of the animal room): 5.2.2.1.

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WebFrequency and doses of cisplatin in nude mice. We would like to test our experimental treatment of cancer on nude mice with xenograft tumor, one of our control groups is cisplatin. Our... WebJun 12, 2024 · Effects of cisplatin (3.5 mg/kg at 72‐h intervals) on UM‐SCC‐22A (A) versus UM‐SCC‐47 (B)‐derived xenograft tumors grown in the flanks of SCID mice were measured at days 0 and 14 (n = 5–8 mice/group, and *P < 0.05 by unpaired Student's t‐test).After the measurement of tumor volumes, CerS1‐6 mRNAs were measured in extracted tumor …

WebAug 14, 2024 · The vehicle control mice were injected with normal saline (cisplatin group) or corn oil (AAI group). After collecting the blood and urine samples from each mouse, the levels of nephrotoxic... WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In …

WebMar 15, 2016 · Cisplatin at 25 mg/kg in PBS (200 μl/animal) was administered by an intraperitoneal injection. Seventy-two hours after cisplatin injection, these mice were euthanized. Another cohort of mice received either 7 or 9 mg/kg cisplatin administered by an intraperitoneal injection once a week for 4 wk. WebDec 5, 2024 · Cisplatin dosage represented the mouse dose equivalent of 75 mg/m 2 IP dose in humans. Mice received 3 treatments, every 2 weeks, starting 14 days after tumor challenge.

WebThe LD 50 was 8.6 mg/kg for free cisplatin and 103.4 mg/kg for cisplatin-loaded nanoparticles, as shown in Table 3. Therefore, compared with free cisplatin, the nanopar- ticles loaded with...

WebDec 23, 2024 · In humans, the volume of peritoneal fluid ranges from 50 to 75 ml ( 7 ), whereas in mice its volume ranges between 0.02 and 0.1 ml ( 8 ). In addition, the peritoneal fluid contains leukocytes and antibodies to fight off infections, and plasma proteins at concentration that is about 50% of what is found in plasma ( 9 ). fishing fabric panelsWebMay 1, 1996 · However, when a dose equal to one-half of the LD50 was administered in each solution to mice with i.p. tumours, survival of mice given the CDDP in hypotonic solution was significantly... can benfotiamine help visionWebCisplatin was positive in a battery of in vitro and in vivo genotoxicity assays to detect mutagenic and clastogenic activity. Carcinogenicity Cisplatin has been shown to be carcinogenic in mice and rats. Secondary malignancies have been reported in cancer … can benfotiamine help non diabetic neuropathyWebcisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did not affect the survival rate of mice and to achieve human-like serum concentrations of … fishing face buffWebMouse IP LD50 40 mg/kg No data available. Material Name: Cisplatin Injection Sodium chloride Molecular Formula: Rat Oral LD50 3000 mg/kg Mixture Mouse Oral LD50 4000 mg/kg Version: 1.0 Cisplatin Mannitol Molecular Weight: Rat Oral LD 50 13500 mg/kg Mixture Rat Oral LD 50 25.8 mg/kg can benfotiamine cause insomnia can bengal cats be declawedWebObjective: The purpose of the study was to investigate the role of peroxidase V (Prx V) in Cisplatin-induced apoptosis of A549 cells and its underlying mechanism. Materials and methods: MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay was conducted to evaluate the regulatory effect of Cisplatin on the survival of A549 cells. can bengal cats eat tuna