WebApr 9, 2024 · Here, we describe that lysine-368 of human citrate synthase is methylated and that the modifying enzyme, localized in the mitochondrial matrix, is methyltransferase-like protein 12 (METTL12), a ... WebGene ID: 103200371, updated on 16-Aug-2024. Summary Other designations. citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial, methyltransferase like 12, methyltransferase like 12
Enzyme Commission Numbers
WebHistone lysine acetylation (Kac) is a hallmark of active or open chromatin, which promotes transcription by neutra- lizing the positive charges of histone, thus weakening its The enzyme citrate synthase E.C. 2.3.3.1 (previously 4.1.3.7)] exists in nearly all living cells and stands as a pace-making enzyme in the first step of the citric acid cycle (or Krebs cycle). Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitocho… free microsoft defender antivirus windows 11
Citrate Synthase - an overview ScienceDirect Topics
WebSep 8, 2024 · Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation September 2024 Journal of Biological ... WebLysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in … WebFeb 28, 2024 · The deduced 466-amino acid protein contains an N-terminal mitochondrial targeting sequence and a motif highly conserved in citrate synthases. Close orthologs … free microsoft cover letter template