WebAug 1, 2024 · ER-phagy receptors connect domains of ER sheets or tubules to the autophagosome biogenesis machinery by binding to members of the ubiquitin-like Atg8 ... suggesting that it is packaged into autophagosomes at these locations. Interestingly, TEX264 contains a gyrase inhibitor-like domain and a long intrinsically disordered … WebMar 7, 2024 · The endoplasmic reticulum (ER) is a major cell compartment where protein synthesis, folding, and posttranslational modifications occur with assistance from a wide variety of chaperones and enzymes. Quality control systems selectively eliminate abnormal proteins that accumulate inside the ER due to cellular stresses. ER-phagy, that is, …
The role of unfolded protein response and ER-phagy in ... - Springer
WebMar 18, 2024 · ER-phagy inhibition is gaining attention as a potentially new therapeutic strategy in cancer, which can be sorted into many kinds of types, including lysosomal … WebER-phagy receptors reside in different ER subdomains. A cross section of an area of sheets (left) and tubules (right) is shown to illustrate the localization of the 6 known mammalian ER membrane ER-phagy receptors. ... one for soluble Z variant of human a-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ. Mol Biol Cell 17, 203 ... switches informatica
Phosphorylation of FAM134C by CK2 controls starvation-induced …
WebNational Center for Biotechnology Information WebMar 18, 2024 · Accordingly, ER-phagy inducers and inhibitors are equally promising in cancer treatment. A brief introduction is given below. 4.1. Activating ER-phagy to Treat Cancer. The induction of ER-phagy can be used as an effective method to accelerate tumor cell death in cancer therapy. For example, disulfiram (DSF) is an anti-alcoholism drug … WebER stress induces the selective autophagy of the ER, a process termed ER-phagy ().Selective autophagy pathways target damaged or superfluous cellular components for degradation via incorporation into an autophagosome, a double-membrane structure whose assembly requires the assembly of a hierarchy of ATG (autophagy-related) gene … switches in computer networking