WebJan 21, 2024 · Fabry disease (FD) is a genetic disorder caused by a-galactosidase A gene mutation. Ultrastructural analysis revealing zebra bodies are the typical morphological characteristics. However, certain tricyclic antidepressants and some other medications could induce renal phospholipidosis mimicking FD. We report a 33-year-old man has been … WebDec 14, 2009 · Phospholipidosis in neurons, the heart, or the eyes might generate more safety concerns. A drug that has the potential to induce PL in terminally differentiated organs such as the eye, the heart, and neurons may require additional monitoring in …

A Strategy for Risk Management of Drug-Induced …

WebThe level of OA in plasma phospholipids in Greece, Italy, and Spain, where olive oil consumption is high, is from 11.2% to 12.7% of total FA. On the other hand, in other … WebPhospholipidosis (intracellular phospholipid accumulation) was observed in multiple organs and tissues (e.g., liver, pancreas, spleen, kidney, lymph nodes, lung, bone marrow, gastrointestinal tract or testes) after repeated oral administration of relugolix in rats and monkeys. ... have any heart problems, including a condition called long QT ... somers town community centre

Phospholipid - an overview ScienceDirect Topics

WebCationic amphiphilic drugs (CADs) include hundreds of FDA-approved agents used to treat a broad spectrum of common diseases, including psychiatric disorders, allergies, heart diseases and infections 6. CADs are characterized by a hydrophobic aromatic ring or ring system and a hydrophilic side chain containing an ionizable amine functional group 7. WebOct 23, 2016 · Phospholipidosis was characterized light microscopically by cytoplasmic enlargement with multivesicular vacuolation of bile ductular epithelium in the liver or the presence of a large clear vacuole occupying the cytoplasm of distal tubular epithelium of the kidney . Glomeruli of the affected kidney appeared to have a few small clear-appearing ... WebPhospholipidosis (PL) is a phospholipid storage disorder, resulting in excessive accumulation of phospholipids in lysosomes of various tissue types [199, 200]. There is a general agreement that inhibition of lysosomal phospholipase A1, A2 and/or C contributes to the accumulation of cationic amphiphilic drug (CADs)–phospholipid complexes. somers town goods yard