WebDec 31, 2024 · Tablet defects such as capping, lamination, or chipping can occur [1] [2] [3]. Tablets can also be too porous or too dense, which may affect the gastric residence time and dissolution rate of the... WebDec 23, 2024 · Formulators can identify a potential capping problem by characterising a formulation’s permeability, which is a fundamental property affecting the tableting process. Entrapped air in a powder blend can reduce interparticle bonding and the tablet’s final tensile strength, both of which can lead to tablet failures like capping.
Finite Element Modeling of Powder Compaction: Mini-Tablets in ...
WebMay 3, 2024 · There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few. Lamination & capping often occur during scale-up … college programs in the philippines
Preventing Capping and other Tablet Defects Natoli Blog
WebJan 9, 2024 · When a sticking defect is noticed on a tablet, one must first identify where the sticking is occurring (upper punch, lower punch or both). The location of the … WebOct 2, 2024 · Tablet flashing, in turn, can cause many other issues after the compression event. When tablets are subjected to de-dusting, the flashed edges may break off and cause rough, poorly defined edges. Tablets with flashing and rough edges can be difficult to film coat and can lead to loose particles adhering to the coated tablet surface. WebSticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing, and yield losses. The capricious nature of the problem means that it can appear at any stage of the development cycle, even when it has been deemed as low risk by models, tests, and previous experience. dr randal reinertson league city tx